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Scientific studies have proven: serum prepared with the EOT®II syringe contains ten times more antiinflammatory proteins and fourty times more growth factors. The product developed by Orthogen was widely analyzed in clinical trials. For example, the German Comission for Pharmaceuticals (Arneimittelkommission) has written in their journal ‘Arzneimittelverordnung in der Praxis’ (Pharmaceutical Application in Practice) in 2012 that a knee osteoarthrithis study with our product was ‘good quality, prospective, randomized, double blinded and placebo controlled’. Especially now, as orthopaedic societies unanimously recommend against using hyluronic acid for treating knee oesteoarthrithis. The general high frequency of invasive surgery is critically commented as well.


Here you will find the most important studies on Orthokine® therapy, which have been published at scientific congresses or journals.

  Treatment of Osteoarthritis of the Knee with a Combination of Autologous Conditioned Serum and Physiotherapy: A Two-Year Observational Study
(Jaime Baselga García-Escudero, Pedro Miguel Hernández Trillos) 2015

  A new treatment for hip osteoarthritis: Clinical evidence for the effectiveness of autologous conditioned serum
(A. W. A. Baltzer, M. S. Ostapczuk, D. Stosch, F. Seidel, M. Granrath) 2013

Investigation into possible differences between ACS monotherapy and ACS combination therapies with cortisone or cortisone + rhlL1Ra.

  Intra-articular administration of autologous conditioned serum (ACS) reduces tibial drill canal distension after ACL reconstruction in a randomised controlled trial
(N. Darabos, M. Haspl, C. Moser, A. Darabos, D. Bartolek, D. Groenemeyer) 2011

Study to investigate the effect of ACS on tibial drill canal distension compared to placebo – with significant results.

  Autologous Conditioned Serum is an effective therapy method for the treatment of osteoarthritis of the knee
(A. W. A. Baltzer, C. Moser, S. A. Jansen, R. Krauspe) 2009

Study to investigate the effect of ACS on the clinical signs and symptoms of osteoarthritis – compared against hyaluronic acid and placebo.

  Autologous Conditioned Serum in the treatment of orthopaedic disorders: The Orthokin®
(P. Wehling, C. Moser, D. Frisbie, C. W. McIlwraith, C. E. Kawac, R. Krauspe, J. A. Reinecke) 2007

Fundamentals of the Orthokin® therapy.

  Efficacy of epidural-perineural injections of autologous conditioned serum in lumbar nerve root compression
(C. Becker MD, S. Heidersdorf MD, S. Drewlo MSc, S. Zirke de Rodriguez, J. Krämer MD, R. E. Willburger MD) 2007

Study on the efficacy of ACS in lumbar nerve root compressions compared to triamcinolone. The result: ACS shows superior pain reduction.

  Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis
(David D. Frisbie, Christopher E. Kawcak, Natasha M. Werpy, Richard Park, C. Wayne McIlwraith) 2007

Observation of clinical, biochemical and histological effects of intra-articular administration of autologous conditioned serum (ACS) in the treatment of experimentally induced arthritis in horses.


  RRelevant studies published for Orthokine® therapy
(Partial list, in alphabetical order)

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